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The 2017 Seventeenth Annual UMM Undergraduate Research Symposium (URS) celebrates student scholarly achievement and creative activities. Students from all disciplines participate in the URS. Types of presentations include posters, oral presentations, and short or abbreviated theatrical, dance, or musical performances. 

Presentations are accompanied by discussions and multimedia.

 


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Saturday, April 22 • 10:00am - 12:00pm
UMCM-1 Protein Adsorption and the Effects of Structural Changes of UMCM-1-NH2 on Protein Adsorption Properties

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MOFs are crystalline compounds containing metal complexes linked by organic compounds. The result of this type of linking is a cage like structure capable of adsorbing other molecules. Although most adsorption studies typically involve gases, MOFs can adsorb other molecules such as peptides, specifically the amyloid-β peptide (Aβ). The misfolding of this peptide causes it to aggregate and form plaques which have been linked to the progression of Alzheimer’s disease. The MOFs UMCM-1 and UMCM-1-NH2 were both tested because they are good candidates for the adsorption of Aβ due to their larger pore size, or larger cage openings, which we found complementary to peptide adsorption. We also made structural changes in the form of additions to the amine group on UMCM-1- NH2. The adsorption capabilities of UMCM-1, UMCM-1-NH2, and the modified UMCM-1-NH2 were examined using both fluorometry and SDS-PAGE. Along with Aβ, insulin and bovine serum were used to check for specific adsorption. The results reveal that all forms of UMCM-1 adsorbed all of the Aβ and insulin present. All of the MOFs also adsorbed all of the bovine serum present with the exception of UMCM-1-Pyridine Imine (UMCM-1-PI) which did not adsorb any of this protein. These data suggest that UMCM-1 and its derivatives are good candidates for the adsorption of Aβ. The results of the trials involving bovine serum suggest that post-synthetic modifications can be used to improve the adsorption specificity of MOFs.

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Saturday April 22, 2017 10:00am - 12:00pm
Student Center, Oyate Hall 600 E 4th St., Morris MN 56267