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The 2017 Seventeenth Annual UMM Undergraduate Research Symposium (URS) celebrates student scholarly achievement and creative activities. Students from all disciplines participate in the URS. Types of presentations include posters, oral presentations, and short or abbreviated theatrical, dance, or musical performances. 

Presentations are accompanied by discussions and multimedia.

 


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Saturday, April 22 • 10:00am - 12:00pm
Investigation of Varying Metal Organic Frameworks for the Use of a Slow Release Mechanism for Insulin

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The protein insulin is key to a properly functioning body, it is produced by the pancreas and allows us to use/store glucose from the carbohydrates we consume. The slow release mechanism is important so it can resemble that of the body. In this research the use of metal organic frameworks was explored as slow release mechanism for insulin. Metal organic frameworks also known as MOFs, are porous materials made from metal ions connected by varying organic ligands, which are electron rich molecules that attach the ions together. These MOFs have tunable pore sizes that allow for adsorption/taken in and desorption/release of small proteins such as insulin. In this case varying MOFs such as H-KUST-1, H-KUST-1/GO (18%) and MOF-5 have been investigated for their ability to adsorb and desorb insulin. The adsorption was done at room temperature and desorption done in phosphate buffered saline in a 37 ℃ (98.6 ℉) waterbath to mock physiological conditions of the human body. Adsorption and desorption were investigated using the techniques of UV-vis, gel electrophoresis, and a fluorometer to find the amount of insulin left in the solution after incubation. Preliminary data shows that a slow release mechanism is promising, seen when the amount of insulin being desorbed/ released from the MOF decreased over time.

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Saturday April 22, 2017 10:00am - 12:00pm
Student Center, Oyate Hall 600 E 4th St., Morris MN 56267