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The 2017 Seventeenth Annual UMM Undergraduate Research Symposium (URS) celebrates student scholarly achievement and creative activities. Students from all disciplines participate in the URS. Types of presentations include posters, oral presentations, and short or abbreviated theatrical, dance, or musical performances. 

Presentations are accompanied by discussions and multimedia.

 


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Saturday, April 22 • 10:00am - 12:00pm
Investigating the Influence of CD80/B7-H1 Signaling on Anti-tumor Immune Responses Mediated by CD8+ T cells

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CD8+ T cells are capable of killing tumor cells, but tumor cells have many ways to evade CD8+ T cells. One mechanism is the expression of B7-H1 (PD-L1) on the surface of tumor cells. Signaling events downstream of B7-H1 interacting with PD-1 on CD8+ T cells result in inhibition of cell proliferation and induction of apoptosis. B7-H1 also interacts with CD80, which is expressed on the surface of CD8+ T cells. The impact of B7-H1 interacting with CD80 is the focus of our studies. In order to study this we use two mouse lines, one wild type line that expressed CD80 and one knockout line that does not express CD80 Utilizing CD8+ T cells harvested from these mice, we have found that activated CD80 knock-out CD8+ T cells survive better than activated wild-type CD8+ T cells when cultured with plate-bound B7-H1 protein and anti-CD3. We are currently investigating the signaling events that occur downstream of B7-H1 interacting with CD80 on effector CD8+ T cells that could contribute to the induction of apoptosis of CD8+ T cells.


Saturday April 22, 2017 10:00am - 12:00pm
Student Center, Oyate Hall 600 E 4th St., Morris MN 56267